Advanced carcinoma of the oropharynx: survival analysis comparing two treatment modalities.

About 92,000 new cases of oropharynx carcinoma are expected to occur annually worldwide. There is no consensus about the best therapy for these advanced tumors. The objective of the present study was to evaluate overall and disease-free survival rates of patients with advanced oropharynx squamous cell carcinoma, comparing surgery + radiotherapy with chemotherapy + radiotherapy. Medical records of patients were reviewed. Previously treated tumors were excluded. Clinical, demographic and microscopic information was collected, and p16 staining was performed. Kaplan-Meier survival curves were plotted. Forty-seven cases were included, 41 men and 6 women, having a mean age of 56.3 years. Most patients were smokers (85.1%) and consumed alcohol (74.5%). Patients were stage III (21.3%) or IV (78.7%). Most lesions affected the base of the tongue (36.2%). Of the 23 cases available for p16 testing, 3 were positive (13.0%). There was no difference between the overall and the disease-free survival rates for the two treatment modalities (p>0.05), even when only resectable tumors were compared. Seventeen cases experienced recurrence (36.2%); 16 (34.0%) patients remained alive without disease; 15 (31.9%) died due to disease; 9 (19.2%) were recurrent at the last follow-up. The two treatment protocols were equally efficient in treating advanced oropharynx squamous cell carcinoma, since both promoted similar overall and disease-free survival rates. The results and interpretations related herein mostly regard "conventional" oropharyngeal squamous cell carcinomas, as opposed to HPV-associated tumors.

Tumor depth of invasion and prognosis of early-stage oral squamous cell carcinoma: A meta-analysis.

OBJECTIVES: To assess the prognosis for early-stage oral squamous cell carcinoma according to tumor depth of invasion (DOI). METHODS: This study was logged in the PROSPERO database under protocol # CRD42017059976. The search was conducted in six electronic databases up to May 2019. Fixed-effects meta-analysis was performed for the calculation of the odds ratio (OR) and respective 95% CI. Primary outcomes were lymph node metastasis, recurrence, and survival. Heterogeneity was calculated by the I2 test. The certainty of evidence was assessed by Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. RESULTS: Twenty-seven studies were included (19 in the meta-analysis) with 2,404 patients with a mean of 60 years of age. High tumor DOI is associated with a greater chance of presenting lymph node metastasis, regardless of the cutoff point for DOI (13 meta-analysis; OR 1.69-53.08), recurrence (five meta-analysis; OR 1.22-3.83), and lower chance of survival (1 meta-analysis; OR 0.49). The certainty of evidence varied from very low to low. CONCLUSIONS: Tumor DOI is a good prognosticator for early-stage OSCC. The findings of the current meta-analysis highlight the clinical relevance of DOI and corroborate its incorporation for staging OSCC.

Advanced carcinoma of the oropharynx: survival analysis comparing two treatment modalities

Abstract About 92,000 new cases of oropharynx carcinoma are expected to occur annually worldwide. There is no consensus about the best therapy for these advanced tumors. The objective of the present study was to evaluate overall and disease-free survival rates of patients with advanced oropharynx squamous cell carcinoma, comparing surgery + radiotherapy with chemotherapy + radiotherapy. Medical records of patients were reviewed. Previously treated tumors were excluded. Clinical, demographic and microscopic information was collected, and p16 staining was performed. Kaplan-Meier survival curves were plotted. Forty-seven cases were included, 41 men and 6 women, having a mean age of 56.3 years. Most patients were smokers (85.1%) and consumed alcohol (74.5%). Patients were stage III (21.3%) or IV (78.7%). Most lesions affected the base of the tongue (36.2%). Of the 23 cases available for p16 testing, 3 were positive (13.0%). There was no difference between the overall and the disease-free survival rates for the two treatment modalities (p>0.05), even when only resectable tumors were compared. Seventeen cases experienced recurrence (36.2%); 16 (34.0%) patients remained alive without disease; 15 (31.9%) died due to disease; 9 (19.2%) were recurrent at the last follow-up. The two treatment protocols were equally efficient in treating advanced oropharynx squamous cell carcinoma, since both promoted similar overall and disease-free survival rates. The results and interpretations related herein mostly regard "conventional" oropharyngeal squamous cell carcinomas, as opposed to HPV-associated tumors.

Câncer de boca e orofaringe em Belo Horizonte: estudo de base hospitalar no período de 2005 a 2015 / Cancer of mouth and oropharynx in Belo Horizonte: hospital-based study in the period from 2005 to 2015

O objetivo do presente estudo foi identificar o perfil dos pacientes com câncer de boca e orofaringe referidos ao Ambulatório de Cirurgia de Cabeça e Pescoço de um hospital público em Belo Horizonte, através da revisão de prontuários dos pacientes atendidos no período de 2005 a 2015. As variáveis estudadas foram: idade, sexo, cor de pele, escolaridade, estado civil, endereço de residência, tabagismo, etilismo, localização do tumor, estadiamento clínico, diagnóstico histológico, tipo de tratamento efetuado, data de ingresso, data de realização da cirurgia e data da última consulta. A análise dos dados envolveu estatística descritiva, comparação das variáveis sociodemográficas e clínicas para o tipo de tratamento e os dois tipos de câncer por meio do teste de chi-quadrado. Adicionalmente foi realizada a análise espacial da distribuição dos casos de câncer de boca e orofaringe. Foram analisados 289 prontuários, a maioria dos pacientes eram do sexo masculino (227), brancos (117), casados (125), com média de idade de 58,6 anos. Quarenta e seis (15,9%) pacientes eram analfabetos e 147 (50,9%) primeiro grau incompleto; 72,7% dos pacientes moravam na região metropolitana de Belo Horizonte. O etilismo e tabagismo estavam presentes em 82,0% e 85,1% dos pacientes respectivamente. As localizações anatômicas mais acometidas foram base da língua, palato mole, assoalho da boca, pilar amigdalino, e borda lateral da língua. O diagnóstico de carcinoma de células escamosas foi reportado em 89,6% dos prontuários. Foi constatado o câncer em grau III e IV (avançado) em 196 (67,8%) pacientes. A média do tempo gasto desde o laudo da biópsia até a consulta no serviço de cabeça e pescoço do HC/UFMG foi 1,5 meses (1,7 DP); e entre a primeira consulta e a data da cirurgia foi 2,9 meses (4,4 DP). Segundo o tipo de câncer, 146 (50,5%) pacientes tinham câncer de boca e 143 (49,5%) câncer de orofaringe, e as comparações revelaram que os pacientes com câncer de orofaringe em comparação com os de boca foram preferivelmente: tabagistas, etilistas, diagnosticados em estádio avançado da doença, com 3 ou mais sítios afetados, receberam tratamento não cirúrgico e residiam a mais de 50km do centro hospitalar. Quanto ao tipo de tratamento efetuado 32,9% somente foram diagnosticados e não continuaram com o tratamento proposto. Quando se compara o tipo de tratamento recebido, as únicas variáveis associadas com a adesão ao tratamento foram o estadiamento clínico inicial (I/II) e ser casado. Na análise espacial foi encontrado que os bairros com maior número de casos estavam localizados principalmente nas regionais Nordeste, Noroeste e Venda Nova. Em relação às variáveis socioeconômicas (baixa renda e moradia em condição semiadequada), foi observado que a maioria dos casos ocorreram em bairros em que estas condições eram piores. Concluindo, o perfil sociodemográfico dos pacientes com câncer de boca não se difere daqueles com câncer de orofaringe atendidos no HC/UFMG

The aim of this study to identify the profiles of patients with oral and oropharyngeal cancer referred to the Departament of Head and Neck Surgery in a public hospital in Belo Horizontem, from 2005 to 2015. Medical records from the hospital were reviewed and the variables studied were age, gender, skin color, years of education, marital status, self-reported home address, smoking status, alcohol consumption, histopathologic diagnostic, the primary tumor location, the type of treatment, tumor staging, and dates of first, last consult and surgery...